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Medications

Trimetazidine (Vastarel® MR)

Last Updated on December 21, 2022

Preparation

  • Tablet

Clinical Use

Anti-ischemic / anti-angina. As ADD-ON therapy for the symptomatic treatment of patients with stable angina pectoris

Mechanism of Action

Trimetazidine prevents a decrease in intracellular ATP levels. This ensures proper functioning of ionic pumps and transmembrane sodium-potassium flow.

Trimetazidine inhibits β-oxidation of fatty acids. This enhances glucose oxidation.
Energy obtained during glucose oxidation requires LESS OXYGEN CONSUMPTION than during ß-oxidation process.

Thus, it maintains proper energy metabolism during myocardial cellular ischaemia.

Dose

  • T Vastarel MR 35 mg BD
  • T Vastarel MR 35 mg OD (creatinine clearance 30 – 60)

Contraindications

  • Parkinson disease
  • Creatinine clearance <30

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