Categories
Medications

Paracetamol / Acetaminophen

Last Updated on July 26, 2022

Introduction

Brand name

Panadol (tablet); Perfalgan (IV)

Mechanism of action / Effects

• Analgesic effect
• Antipyretic effect
• Anti-inflammatory activity (weak)

Route of administration

• Oral (tablet / syrup)
• IV
• Rectal

Pharmacokinetics

Onset

• Oral: <1 hour
• IV: 5 – 10 minutes (analgesia); within 30 minutes (antipyretic)

Peak of action

• Oral: 30 mins – 2 hours
• IV: 15 mins
• Rectal: 2 – 3 hours

Duration

• Oral: 4 – 6 hours
• IV: 4 – 6 hours (analgesia); ≥6 hours (antipyretic)

Metabolism

• Mainly in liver

Excretion

• Elimination half-life: 1-4 hours

Dosage

Fever, Mild to moderate pain

Precaution

• G6PD deficiency
• Chronic alcoholism or malnutrition.
• Renal impairment
• Hepatic impairment

Further Reading

  1. MIMS

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