D-Dimer

Last Updated on August 24, 2022

Normal Value

Causes of Increased D-Dimer

• Thromboembolism
• Sepsis (organ dysfunction → raised D-dimer)
etc.

Sensitivity / Specificity

Sensitivity / specificity in thromboembolism:
• Sensitivity: >95%
• Specificity: 61 – 64%
• Negative predictive values: 99%

Thus,
• Positive D-Dimer alone cannot diagnose VTE
• Negative D-Dimer can exclude VTE

Reference

1. The Sensitivity and Specificity of a Red Blood Cell Agglutination D-Dimer Assay for Venous Thromboembolism When Performed on Venous Blood
2. D-dimer testing in the treatment and monitoring of septic patients