Last Updated on November 4, 2022
Mechanism of action
Dihydropyridine
• Vasodilatation → decreased peripheral resistance
Non-dihydropyridine
• Negative inotropic effect
Classification
• Dihydropyridine vs Non-dihydropyridine
Calcium channel blockers in hypertension
Dihydropridines | Starting dose | Recommended maximum daily dose | Remark |
5 mg OD | 10 mg OD | ||
5 mg OD | 10 mg BD | ||
Isradipine | 2.5 mg BD | 10 mg OD | |
Lercanidipine | 10 mg OD | 20 mg OD | |
5 mg TDS | 20 mg TDS | ||
Nicardipine | - | - | |
Non-Dihydropridines | Starting dose | Recommended maximum daily dose | Remark |
90 mg BD | 180 mg BD | ||
Diltiazem SR | 100 mg OD | 200 mg OD | |
80 mg TDS | 160 mg TDS | ||
Verapamil SR | 120 mg OD | 480 mg OD |